The effects of superparamagnetic iron oxide nanoparticle exposure on gene expression patterns in the neural stem cells under magnetic field
Background: Due to the excellent reliable traceability and superparamagnetic properties, superparamagnetic iron oxide nanoparticles (SPIOs) are widely used for the applications in the field of biomedicine, including tissue engineering and regenerative medicine. However, the regulation of SPIOs on the gene expressions in the stem cells is not clear.
Methods: In this study, by RNA-Seq analysis, we analyzed the gene expression pattern in the neural stem cells (NSCs) treated with SPIOs in the presence or absence of static magnetic field (SMF).
Results: It was found that SPIOs with SMF regulated more gene expression in NSCs, while most of these genes have been previously reported to play a crucial role in NSCs fate decision.
Conclusions: Our findings reveal the ability of SPIOs and SMF in the regulation of gene expression in NSCs, which may provide an experimental basis for its applications.
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