Misfolded protein aggregation and altered cellular pathways in neurodegenerative diseases

  • Huifang Li College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China. National Experimental Teaching Demonstration Center of Animal Science, Nanjing Agricultural University, Nanjing 210095, China.
  • Zhenghong Yu Department of Rheumatology and Immunology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China.
  • Wei Zhang College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China. National Experimental Teaching Demonstration Center of Animal Science, Nanjing Agricultural University, Nanjing 210095, China.
Keywords: Neurodegenerative diseases, misfolded protein aggregates, Unfolded protein response, Protein clearance pathways, Insulin/IGF/TOR

Abstract

Neurodegenerative diseases are estimated by the World Health Organization to be the second leading cause of human death by 2050. They actually are a group of chronic neurological disorders leading to motor, cognitive and sensory impairments in both human and nonhuman species. Despite different in clinical manifestation, prevalence, risk factors, cell types injured and genes hijacked, neurodegenerative disorders are usually associated with the misfolding and aggregation of a distinct protein that accumulates in diverse cellular locations including the nucleus, cytoplasm, plasma membrane and extracellular space. Here we intend to give an overview of the characters and features of several pathogenic protein aggregates in disease brains, and introduce some general signaling pathways involved in protein homeostasis with emphasis on their puzzling roles under the degenerative conditions.

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Published
2020-09-23
How to Cite
Li, H., Yu, Z., & Zhang, W. (2020). Misfolded protein aggregation and altered cellular pathways in neurodegenerative diseases. STEMedicine, 1(4), e63. https://doi.org/10.37175/stemedicine.v1i4.63
Section
Review articles