Multivariable analysis for complete resection rate of 10-20 mm non-metastatic rectal neuroendocrine tumors: a retrospective clinical study

  • Xinqiang Zhu 1Department of General Surgery, the Second Affiliated Hospital of Soochow University, No.1055 Sanxiang Road, Suzhou 215004, Jiangsu, China. 2 Department of General Surgery, the Affiliated Suqian Hospital of Xuzhou Medical University, No.138 Huanghe South Road, Suqian 223800, Jiangsu, China
  • Gang Zhou Department of Gastrointestinal Pancreatic Surgery, the Affiliated Jiangning Hospital of Nanjing Medical University, NO.169 Hushan Road, Nanjing 211100, Jiangsu, China
  • Linchun Wen Department of Oncology, the Affiliated Suqian Hospital of Xuzhou Medical University, No.138 Huanghe South Road, Suqian 223800, Jiangsu, China
  • Jianing Liu Department of Digestive, the Affiliated Suqian Hospital of Xuzhou Medical University, No.138 Huanghe South Road, Suqian 223800, Jiangsu, China
  • Xuetong Jiang Department of General Surgery, the Affiliated Suqian Hospital of Xuzhou Medical University, No.138 Huanghe South Road, Suqian 223800, Jiangsu, China
  • Jianqiang Wu Department of General Surgery, the Affiliated Suqian Hospital of Xuzhou Medical University, No.138 Huanghe South Road, Suqian 223800, Jiangsu, China
  • Hailong Huang Department of General Surgery, the Affiliated Suqian Hospital of Xuzhou Medical University, No.138 Huanghe South Road, Suqian 223800, Jiangsu, China
  • Xiaohong Shi Department of Pathology, the Affiliated Suqian Hospital of Xuzhou Medical University, No.138 Huanghe South Road, Suqian 223800, Jiangsu, China
  • Xiaoling Jiang Department of Pathology, the Affiliated Suqian Hospital of Xuzhou Medical University, No.138 Huanghe South Road, Suqian 223800, Jiangsu, China
  • Chungen Xing Department of General Surgery, the Second Affiliated Hospital of Soochow University, No.1055 Sanxiang Road, Suzhou 215004, Jiangsu, China
Keywords: Rectal neuroendocrine tumors, Multivariable analysis, Transanal local excision, Endoscopic submucosal dissectionscriptome, Metastasis

Abstract

Background: This retrospective study aimed to identify key factors affecting the rate of complete resection for non-metastatic rectal neuroendocrine tumors (NETs) using both transanal local excision (TLE) and endoscopic submucosal dissection (ESD).
Methods: Records in the past 10 years were retrieved, for a total of 95 patients diagnosed with non-metastatic rectal NETs sized between 10-20 mm. Treatment outcomes were first compared between TLE and ESD to identify significantly associated factors. Monofactor analysis was then performed between complete and local resections to identify risk factors, which were then subjected to a multivariable analysis to identify independent risk factors.
Results: Treatment outcomes between TLE and ESD were significantly associated with depth of invasion (P=0.039) and complete/local resection (P=0.048). By monofactor analysis between complete and local resections, depth of invasion, tumor size, tumor stage and endoscopic manifestation were identified to be risk factors (P=0.014, 0.003, 0.002 and 0.028, respectively). In subsequent multivariable analysis, depth of invasion and tumor size were independent risk factors, with odds ratio of 18.838 and 37.223, and 95% confidence interval of 1.242-285.800 and 2.839-488.078, respectively.
Conclusion: Depth of invasion and tumor size were independent risk factors that significantly affect the complete resection rate of 10-20 mm non-metastatic rectal NETs.

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References

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Published
2021-06-14
How to Cite
Zhu , X., Zhou, G., Wen, L., Liu, J., Jiang, X., Wu , J., Huang, H., Shi, X., Jiang, X., & Xing, C. (2021). Multivariable analysis for complete resection rate of 10-20 mm non-metastatic rectal neuroendocrine tumors: a retrospective clinical study. STEMedicine, 2(7), e89. https://doi.org/10.37175/stemedicine.v2i7.89
Section
Research articles