https://stemedicine.org/index.php/stem/issue/feed 2024-04-29T01:48:29+08:00 Editorial Office journal.manager@stemedicine.org Open Journal Systems <p><strong>STEM</strong><strong>edicine (ISSN 2705-1188)</strong> is an Open Access, peer-reviewed journal published by <a href="http://www.innovationpublishing.org/" target="_blank" rel="noopener">Innovation Publishing House Pte. Ltd.</a> on a quarterly basis under the CC BY 4.0 license. We established <em>STEMedicine </em>with the goal to bring researchers and practitioners together on our platform, in order to share scientific discoveries and technological advances both in biology and medicine.</p> https://stemedicine.org/index.php/stem/article/view/191 2024-04-29T01:48:29+08:00 Yuchao Shen littlefive@163.com Ying Cui cuiying73@sina.com

<p><strong>Background: </strong>Septic shock can lead to multiple organ dysfunction. The cholinergic anti-inflammatory pathway is known to prevent organ damage from infection by modulating the inflammatory response. However, the modulatory capacity of cholinergic anti-inflammatory pathways in septic shock remains unclear.</p> <p><strong>Methods:</strong> Cecal ligation and puncture (CLP) was used to establish a rat model of septic shock. Bilateral cervical vagal nerve isolation, dual cervical vagotomy, and vagus nerve stimulation (VNS) were used to inhibit or activate cholinergic anti-inflammatory pathways. Tacrine and α-bungarotoxin groups were used to mimic the activation and shutdown of cholinergic anti-inflammatory pathways. The survival status, hemodynamic indicators, inflammatory cytokine content, and inflammatory response of liver and kidney tissues of the rats were detected.</p> <p><strong>Results: </strong>Dual cervical vagotomy significantly exacerbated the hepatic (p &lt; 0.05) and renal (p &lt; 0.05) impairment in septic shock rats relative to the sham-operated group. Tacrine, a cholinergic potentiator, significantly alleviated liver (p &lt; 0.05) and kidney (p &lt; 0.05) damage in septic shock rats. Dual cervical vagotomy significantly promoted the expression of pro-inflammatory factors caused by septic shock in rat liver and kidney tissues (p &lt; 0.05), while Tacrine treatment inhibited the increase of inflammatory factors (p &lt; 0.05).</p> <p><strong>Conclusions:</strong> Activation of the cholinergic anti-inflammatory pathway exerts protective effects on multiple organ dysfunction caused by septic shock. The cholinergic enhancer, Tacrine, and VNS effectively ameliorated liver and kidney damage, improved hemodynamic indicators, and enhanced survival rates in septic shock rats.</p>

2024-04-07T08:38:06+08:00 Copyright (c) 2024 Yuchao Shen, Ying Cui