https://stemedicine.org/index.php/stem <p><strong>STEM</strong><strong>edicine (ISSN 2705-1188)</strong> is an Open Access, peer-reviewed journal published by <a href="http://www.innovationpublishing.org/" target="_blank" rel="noopener">Innovation Publishing House Pte. Ltd.</a> on a quarterly basis under the CC BY 4.0 license. We established <em>STEMedicine </em>with the goal to bring researchers and practitioners together on our platform, in order to share scientific discoveries and technological advances both in biology and medicine.</p> en-US <p>Authors retain full copyright to their individual works, and publishing rights without restrictions.</p> <p>In accordance with the <a href="https://www.budapestopenaccessinitiative.org/">Budapest Open Access Initiative</a>, articles published in <em>STEMedicine</em> are freely available "on the public internet, permitting any users to read, download, copy, distribute, print, search, or link to the full texts of these articles, crawl them for indexing, pass them as data to software, or use them for any other lawful purpose, without financial, legal, or technical barriers other than those inseparable from gaining access to the internet itself. The only constraint on reproduction and distribution, and the only role for copyright in this domain, should be to give authors control over the integrity of their work and the right to be properly acknowledged and cited."</p> <p>Except where otherwise noted, all content on this website is licensed under a <a href="https://creativecommons.org/licenses/by/4.0" target="_blank" rel="noopener">Creative Commons Attribution 4.0 License</a>. This license allows for commercial and non-commercial redistribution as well as modifications of the work as long as attribution is given to the authors and <em>STEMedicine</em> as the original publication source, and a link to the article on the <em>STEMedicine</em> website is provided.</p> journal.manager@stemedicine.org (Editorial Office) journal.manager@stemedicine.org (Editorial Office) Sun, 28 Apr 2024 09:26:36 +0800 OJS 3.1.2.0 http://blogs.law.harvard.edu/tech/rss 60 https://stemedicine.org/index.php/stem/article/view/191 <p><strong>Background: </strong>Septic shock can lead to multiple organ dysfunction. The cholinergic anti-inflammatory pathway is known to prevent organ damage from infection by modulating the inflammatory response. However, the modulatory capacity of cholinergic anti-inflammatory pathways in septic shock remains unclear.</p> <p><strong>Methods:</strong> Cecal ligation and puncture (CLP) was used to establish a rat model of septic shock. Bilateral cervical vagal nerve isolation, dual cervical vagotomy, and vagus nerve stimulation (VNS) were used to inhibit or activate cholinergic anti-inflammatory pathways. Tacrine and α-bungarotoxin groups were used to mimic the activation and shutdown of cholinergic anti-inflammatory pathways. The survival status, hemodynamic indicators, inflammatory cytokine content, and inflammatory response of liver and kidney tissues of the rats were detected.</p> <p><strong>Results: </strong>Dual cervical vagotomy significantly exacerbated the hepatic (p &lt; 0.05) and renal (p &lt; 0.05) impairment in septic shock rats relative to the sham-operated group. Tacrine, a cholinergic potentiator, significantly alleviated liver (p &lt; 0.05) and kidney (p &lt; 0.05) damage in septic shock rats. Dual cervical vagotomy significantly promoted the expression of pro-inflammatory factors caused by septic shock in rat liver and kidney tissues (p &lt; 0.05), while Tacrine treatment inhibited the increase of inflammatory factors (p &lt; 0.05).</p> <p><strong>Conclusions:</strong> Activation of the cholinergic anti-inflammatory pathway exerts protective effects on multiple organ dysfunction caused by septic shock. The cholinergic enhancer, Tacrine, and VNS effectively ameliorated liver and kidney damage, improved hemodynamic indicators, and enhanced survival rates in septic shock rats.</p> Yuchao Shen, Ying Cui Copyright (c) 2024 Yuchao Shen, Ying Cui https://creativecommons.org/licenses/by/4.0 https://stemedicine.org/index.php/stem/article/view/191 Sun, 07 Apr 2024 08:38:06 +0800