Plasmonic nanoassemblies for surface-enhanced Raman scattering-based biodetection and biomedical theranostics

Yi Chen; Yu Bai; Heng Zhang; Zheng Zhou

doi:10.37175/stemedicine.v3i4.147

Yi Chen State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing, China; and Southeast University-Monash University Joint Research Institute, Suzhou, China
Yu Bai State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing, China; and Southeast University-Monash University Joint Research Institute, Suzhou, China
Heng Zhang State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing, China; and Southeast University-Monash University Joint Research Institute, Suzhou, China
Zheng Zhou State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing, China; and Southeast University-Monash University Joint Research Institute, Suzhou, China

DOI: https://doi.org/10.37175/stemedicine.v3i4.147

Keywords: plasmonic, nanoassemblies, surface-enhanced Raman scattering, biodetection, theranostics

Abstract

Plasmonic nanoassemblies are well-defined organizing of elementary metallic nanocrystal building blocks into ordered architectures across multiple scales, which constituents an exciting route to engineer nanomaterials structures with novel properties. Such nanoassemblies can accurately enhance, guide, and switch electromagnetic field at the nanoscale, which is shaping new-generation technologies with a plethora of applications, such as ultrasensitive bimolecular sensors, cancer diagnostics, and photothermal therapy (PTT), to name a few. In this review, we mainly focus on the plasmonic nanoassemblies, including the structure design, property control, and biomedical applications. The guiding principles have been first clarified with design rules being suggested. Then, the methodologies for fabrication of surface-enhanced Raman scattering-based (SERS-based) biodetection devices have been discussed. Finally, we summarized the PTT by using the plasmonic nanoassemblies as bioprobes for theranostics. Based on the facile yet efficient fabrication methods, high-efficient optoelectronic properties, and high performance in biomedical applications, we firmly believe that the plasmonic nanoassemblies can be integrated with portable devices for next-generation biosensors and biomedical theranostics.

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