Regulatory effect of anisotropic structure on cardiomyocyte maturation

  • Yue Xu Institute for Cardiovascular Science & Department of Cardiovascular Surgery of the First Affiliated Hospital, Medical College, Soochow University, Suzhou, China
  • Miao Xiao Institute for Cardiovascular Science & Department of Cardiovascular Surgery of the First Affiliated Hospital, Medical College, Soochow University, Suzhou, China
  • Xiaoyun Li Institute for Cardiovascular Science & Department of Cardiovascular Surgery of the First Affiliated Hospital, Medical College, Soochow University, Suzhou, China
  • Ziyun Jiang Institute for Cardiovascular Science & Department of Cardiovascular Surgery of the First Affiliated Hospital, Medical College, Soochow University, Suzhou, China
Keywords: Cardiovascular disease, human pluripotent stem cells, cardiomyocytes, bioengineering, anisotropic structure


Cardiovascular disease (CVD) is the leading cause of death worldwide. Due to the limited regenerative capacity of the adult heart, treatments based on human pluripotent stem cells (hPSCs) have become the focus of a great deal of research. Human pluripotent stem cell–derived cardiomyocytes (hPSC-CMs) can provide an ideal cell source for CVD model construction, cardiac tissue repair, and drug cardiotoxicology research. However, the immaturity of hPSC-CMs seriously restricts its clinical application. The maturation of cardiomyocytes depends on the orderly arrangement of myofilaments and the increase of the expression of connexin, so the geometric regulation of bioengineering substrate is one of the keys to the maturation of engineered myocardial tissue. This review focuses on the key indicators of anisotropic structures provided by biomaterials to improve the maturation characteristics of cardiomyocytes, so as to promote the maturation of cardiomyocytes, and looks forward to the development direction in this field.


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How to Cite
XuY., XiaoM., LiX., & JiangZ. (2023). Regulatory effect of anisotropic structure on cardiomyocyte maturation. STEMedicine, 4(3), e179.
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