Spinal cord neural stem cells heterogeneity in postnatal development

  • Jelena Ban Laboratory for Molecular Neurobiology, Department of Biotechnology, University of Rijeka, Croatia
  • Miranda Mladinic Laboratory for Molecular Neurobiology, Department of Biotechnology, University of Rijeka, Croatia https://orcid.org/0000-0002-3985-6629
Keywords: Neural stem cells, Radial glia, Ependymal cells, Development, Spinal cord injury

Abstract

Neural stem cells are capable of generating new neurons during development as well as in the adulthood and represent one of the most promising tools to replace lost or damaged neurons after injury or neurodegenerative disease. Unlike the brain, neurogenesis in the adult spinal cord is poorly explored and the comprehensive characterization of the cells that constitute stem cell neurogenic niche is still missing. Moreover, the terminology used to specify developmental and/or anatomical CNS regions, where neurogenesis in the spinal cord occurs, is not consensual and the analogy with the brain is often unclear. In this review, we will try to describe the heterogeneity of the stem cell types in the spinal cord ependymal zone, based on their origin and stem cell potential. We will also consider specific animal in vitro models that could be useful to identify “the right” stem cell candidate for cell replacement therapies.   

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Published
2020-01-02
How to Cite
Ban, J., & Mladinic, M. (2020). Spinal cord neural stem cells heterogeneity in postnatal development. STEMedicine, 1(1), e19. https://doi.org/10.37175/stemedicine.v1i1.19
Section
Review articles