Unfolding the pathogenesis of systemic sclerosis through epigenomics

  • Xiuzhi Jia Central Lab of Biomedical Research Center, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, China
  • Hao Cheng Department of Dermatology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, China
  • Ying Xiao Central Lab of Biomedical Research Center, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, China
Keywords: Epigenetics, Methylation, Histone modification, microRNA, Systemic sclerosis

Abstract

As a group of autoimmune diseases, systemic sclerosis (scleroderma, SSc) is characterized by immune dysregulation, micro-vessels dominant obliteration, and the final fibrosis of the skin and or internal organs. Although the precise mechanisms are still unknown, increasing data shows that epigenetic mechanisms, such as DNA methylation, histone modification, and microRNA (miRNA), are strictly related to the pathogenesis of scleroderma. Epigenetic mechanisms, which can link genetics and environmental stress, represents a promising field in systemic sclerosis investigation. The objective of this review is, to sum up the current information about epigenetic alteration.

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Published
2020-01-02
How to Cite
Jia, X., Cheng, H., & Xiao, Y. (2020). Unfolding the pathogenesis of systemic sclerosis through epigenomics. STEMedicine, 1(1), e5. https://doi.org/10.37175/stemedicine.v1i1.5
Section
Review articles